Glycopeptide resistance amongst Staphylococcus spp.
نویسندگان
چکیده
منابع مشابه
Detection of glycopeptide resistance in Staphylococcus aureus.
Sir, We have a number of comments regarding the recent letter from Aucken et al. describing a study of the incidence of GISA (glycopeptide-intermediate Staphylococcus aureus) in the UK using a number of different methodologies at different times. The emergence of S. aureus with reduced susceptibility to glycopeptides (particularly vancomycin), whilst a significant threat also poses interesting ...
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Staphylococcus aureus and coagulase-negative Staphylococcus (CoNS) are the main agents of nosocomial infections. The antimicrobial resistance of these microorganisms has increased worldwide, justified by the selective pressure caused by the use of broad spectrum antibiotics. The prophylactic antibioticotherapy is also a concerning factor, because it increases the risk of infection, and difficul...
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The selective pressure resulting from the extensive use of antibiotics over the last 50 years has led to the emergence of bacterial resistance and to the dissemination of resistance genes among pathogenic microorganisms. Consequently, we are now at serious risk of suffering intractable, life-threatening infections. The progressive emergence and rapid dissemination of resistance to glycopeptides...
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The mechanism of high-level resistance to vancomycin in enterococci consists of the synthesis of peptidoglycan terminating in D-alanyl-D-lactate instead of the usual D-alanyl-D-alanine. This alternate cell wall biosynthesis pathway is ensured by the collective actions of three enzymes: VanH, VanA, and VanX. The origin of this resistance mechanism is unknown. We have cloned three genes encoding ...
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Understanding in detail the factors which permit Staphylococcus aureus to counteract cell wall-active antibiotics is a prerequisite to elaborating effective strategies to prolong the usefulness of these drugs and define new targets for pharmacological intervention. Methicillin-resistant S. aureus (MRSA) strains are major pathogens of hospital-acquired and community-acquired infections and are m...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 1998
ISSN: 1460-2091
DOI: 10.1093/jac/42.5.673